VPC-80051 racemate

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

VPC-80051是第一个利用计算机辅助药物发现方法抑制hnRNP A1剪接活性的小分子抑制剂。

VPC-80051 is the first small molecule inhibitor of hnRNP A1 splicing activity by using a computer-aided drug discovery approach.(In Vitro):VPC-80051 interacts directly with hnRNP A1 RBD and reduces AR-V7 messenger levels in 22Rv1 CRPC cell line.

VPC-80051 interacts directly with hnRNP A1 RBD and reduces AR-V7 messenger levels in 22Rv1 CRPC cell line. hnRNP A1 is a multifunctional RNA-binding protein that regulates alternative pre-mRNA splicing, transcription, nucleocytoplasmic shuttling, miRNA processing, and telomere elongation maintenance, as well as translation of cellular transcripts both in physiological and pathological conditions.

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VPC-80051

Others

Other Targets

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877969-69-2

301.29

C16H13F2N3O

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (331.91 mM)

CC(c(cc1)cc(F)c1F)NC(c1n[nH]c2c1cccc2)=O

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(-20℃)

With Ice Pack

≥ 2 years